Cureus, Choices and Challenges With Drug Therapy in Postural Orthostatic Tachycardia Syndrome: A Systematic Review
The literature on pharmacologic treatments for postural orthostatic tachycardia syndrome (POTS) is inconsistent and unstandardized. Therefore, we aimed to evaluate choices in pharmacologic treatment options for POTS and the challenges encountered in the studies. We searched numerous databases like PubMed, Scopus, Embase, Web of Science, and Google Scholar for literature published before April 8, 2023. The search was done to retrieve potential peer-reviewed articles that explored drug therapy in POTS. Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines were used to conduct the systematic review. Of the 421 potential articles assessed, 17 met the inclusion criteria. Results demonstrated that pharmacologic treatment options for POTS were effective in reducing symptoms of POTS, but most of the studies were underpowered. Several were terminated due to various reasons. Midodrine ivabradine, bisoprolol, fludrocortisone, droxidopa, desmopressin, propranolol, modafinil, methylphenidate, and melatonin have been studied with positive impact but sample sizes that were low in the range of 10-50 subjects. Therefore, we concluded the treatment options effectively improve symptoms of POTS and increase orthostatic tolerance, but more evidence is needed as most studies had a low sample size and thus are underpowered.
JPM, Free Full-Text
Autonomic Dysfunction And Postural Orthostatic Tachycardia, 49% OFF
2015 ACC/AHA/HRS Guideline for the Management of Adult Patients With Supraventricular Tachycardia: Executive Summary
Inderbir Padda, MD MPH - PGY-2 Internal Medicine Resident - Richmond University Medical Center
Frontiers Postural Tachycardia Syndrome in Children and Adolescents: Pathophysiology and Clinical Management
Autonomic Dysfunction And Postural Orthostatic Tachycardia, 49% OFF
JPM, Free Full-Text
News
Frontiers ME/CFS and Long COVID share similar symptoms and biological abnormalities: road map to the literature
Distinct Hemodynamic Responses That Culminate With Postural Orthostatic Tachycardia Syndrome - ScienceDirect
Apparent risks of postural orthostatic tachycardia syndrome diagnoses after COVID-19 vaccination and SARS-Cov-2 Infection
Understanding and Managing Postural Orthostatic Tachycardia Syndrome
POTS Treatment: Scientifically & Medically Proven • MyHeart
4 Ehlers-Danlos Syndromes and Hypermobility Spectrum Disorders, Selected Heritable Disorders of Connective Tissue and Disability
