Identification and Strategies to Mitigate High Total Clearance of

Christina CHAN, Researcher, PhD, AstraZeneca, London

PDF) A-loop interactions in Mer tyrosine kinase give rise to

PDF) Predicting when Biliary Excretion of Parent Drug is a Major

Optimization of an Imidazo[1,2- a ]pyridine Series to Afford

MerTK in complex with EX172 (PDB entry 7AAZ). The kinase domain N

EX172 is a selective MerTK/Axl inhibitor. The compound was tested

Prediction of Human Renal Clearance from Preclinical Species for a

Physicochemical Determinants of Human Renal Clearance

TAM receptors and the clearance of apoptotic cells

William MCCOULL, AstraZeneca, London, AZ